Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis
Identifieur interne : 000177 ( France/Analysis ); précédent : 000176; suivant : 000178Perspectives for integrating human and environmental risk assessment and synergies with socio-economic analysis
Auteurs : Alexandre Pery [France] ; Gerrit Schuurmann [Allemagne] ; Philippe Ciffroy [France] ; Michael Faust [Allemagne] ; T. Backhaus [Allemagne] ; Lothar Aicher [Suisse] ; Enrico Mombelli [France] ; Cléo Tebby [France] ; Mark Cronin [Royaume-Uni] ; Sylvie Tissot [Suisse] ; Sandrine Andres [France] ; Jean-Marc Brignon [France] ; L. Frewer [Royaume-Uni] ; S. Georgiou [Royaume-Uni] ; K. Mattas [Grèce] ; J. C. Vergnaud [France] ; W. Peijnenburg [Pays-Bas] ; Ettore Capri [Italie] ; A. Marchis [Italie] ; Martin Wilks [Suisse]Source :
- Science of the Total Environment [ 0048-9697 ] ; 2013.
Descripteurs français
- mix :
Abstract
For more than a decade, the integration of human and environmental risk assessment (RA) has become an attractive vision. At the same time, existing European regulations of chemical substances such as REACH (EC Regulation No. 1907/2006), the Plant Protection Products Regulation (EC regulation 1107/2009) and Biocide Regulation (EC Regulation 528/2012) continue to ask for sector-specific RAs, each of which have their individual information requirements regarding exposure and hazard data, and also use different methodologies for the ultimate risk quantification. In response to this difference between the vision for integration and the current scientific and regulatory practice, the present paper outlines five medium-term opportunities for integrating human and environmental RA, followed by detailed discussions of the associated major components and their state of the art. Current hazard assessment approaches are analyzed in terms of data availability and quality, and covering non-test tools, the integrated testing strategy (ITS) approach, the adverse outcome pathway (AOP) concept, methods for assessing uncertainty, and the issue of explicitly treating mixture toxicity. With respect to exposure, opportunities for integrating exposure assessment are discussed, taking into account the uncertainty, standardization and validation of exposure modeling as well as the availability of exposure data. A further focus is on ways to complement RA by a socio-economic assessment (SEA) in order to better inform about risk management options. In this way, the present analysis, developed as part of the EU FP7 project HEROIC, may contribute to paving the way for integrating, where useful and possible, human and environmental RA in a manner suitable for its coupling with SEA.
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Hal:ineris-00961805Le document en format XML
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status="INCOMING"><orgName>Liverpool University</orgName><desc><address><country key="GB"></country></address></desc><listRelation><relation active="#struct-364795" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-364795" type="direct"><org type="institution" xml:id="struct-364795" status="INCOMING"><orgName>LIVERPOOL UNIVERSITY</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Tissot, Sylvie" sort="Tissot, Sylvie" uniqKey="Tissot S" first="Sylvie" last="Tissot">Sylvie Tissot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247488" status="INCOMING"><orgName>SYNGENTA Crop protection AG</orgName><desc><address><country key="CH"></country></address></desc><listRelation><relation active="#struct-359072" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-359072" type="direct"><org type="institution" xml:id="struct-359072" status="INCOMING"><orgName>SYNGENTA Crop protection AG</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Suisse</country></affiliation></author><author><name sortKey="Andres, Sandrine" sort="Andres, Sandrine" uniqKey="Andres S" first="Sandrine" last="Andres">Sandrine Andres</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3186" status="VALID"><orgName>Institut National de l'Environnement Industriel et des Risques</orgName><orgName type="acronym">INERIS</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.ineris.fr/</ref></desc><listRelation><relation active="#struct-300023" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300023" type="direct"><org type="institution" xml:id="struct-300023" status="VALID"><orgName>INERIS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Brignon, Jean Marc" sort="Brignon, Jean Marc" uniqKey="Brignon J" first="Jean-Marc" last="Brignon">Jean-Marc Brignon</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3186" status="VALID"><orgName>Institut National de l'Environnement Industriel et des Risques</orgName><orgName type="acronym">INERIS</orgName><desc><address><country key="FR"></country></address><ref type="url">http://www.ineris.fr/</ref></desc><listRelation><relation active="#struct-300023" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300023" type="direct"><org type="institution" xml:id="struct-300023" status="VALID"><orgName>INERIS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Frewer, L" sort="Frewer, L" uniqKey="Frewer L" first="L." last="Frewer">L. Frewer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247489" status="INCOMING"><orgName>Food and Society Centre for Rural Economy</orgName><desc><address><country key="GB"></country></address></desc><listRelation><relation active="#struct-252912" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"><orgName>Newcastle University [Newcastle]</orgName><desc><address><addrLine>Newcastle upon Tyne NE1 7RU</addrLine><country key="GB"></country></address><ref type="url">http://www.ncl.ac.uk/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Georgiou, S" sort="Georgiou, S" uniqKey="Georgiou S" first="S." last="Georgiou">S. Georgiou</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247490" status="INCOMING"><orgName>Chemicals Regulation Directorate, Health and Safety Executive</orgName><desc><address><country key="GB"></country></address></desc><listRelation><relation active="#struct-359073" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-359073" type="direct"><org type="institution" xml:id="struct-359073" status="INCOMING"><orgName>Chemicals Regulation Directorate, Health and Safety Executive</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Mattas, K" sort="Mattas, K" uniqKey="Mattas K" first="K." last="Mattas">K. Mattas</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-65960" status="INCOMING"><orgName>Aristotelian University of Thessaloniki</orgName><desc><address><country key="GR"></country></address></desc><listRelation><relation active="#struct-303184" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-303184" type="direct"><org type="institution" xml:id="struct-303184" status="VALID"><orgName>Aristotle University of Thessaloniki</orgName><desc><address><addrLine>University Campus 54124 Thessaloniki Greece</addrLine><country key="GR"></country></address><ref type="url">http://www.auth.gr/en</ref></desc></org></tutelle></tutelles></hal:affiliation><country>Grèce</country></affiliation></author><author><name sortKey="Vergnaud, J C" sort="Vergnaud, J C" uniqKey="Vergnaud J" first="J. C." last="Vergnaud">J. C. Vergnaud</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-15080" status="VALID"><orgName>Centre d'économie de la Sorbonne</orgName><orgName type="acronym">CES</orgName><desc><address><addrLine>Maison des Sciences Économiques - 106-112 Boulevard de l'Hôpital - 75647 Paris Cedex 13</addrLine><country key="FR"></country></address><ref type="url">http://centredeconomiesorbonne.univ-paris1.fr/</ref></desc><listRelation><relation active="#struct-7550" type="direct"></relation><relation name="UMR8174" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-7550" type="direct"><org type="institution" xml:id="struct-7550" status="VALID"><orgName>Université Panthéon-Sorbonne</orgName><orgName type="acronym">UP1</orgName><desc><address><addrLine>12 place du Panthéon - 75231 Paris Cedex 05</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-paris1.fr/</ref></desc></org></tutelle><tutelle name="UMR8174" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="IdRef">02636817X</idno><idno type="ISNI">0000000122597504</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Peijnenburg, W" sort="Peijnenburg, W" uniqKey="Peijnenburg W" first="W." last="Peijnenburg">W. Peijnenburg</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-62631" status="INCOMING"><orgName>National Institute for Public Health and the Environment</orgName><desc><address><country key="NL"></country></address></desc><listRelation><relation active="#struct-315358" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-315358" type="direct"><org type="institution" xml:id="struct-315358" status="INCOMING"><orgName>National Institute for Public Health and the Environment</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Pays-Bas</country></affiliation></author><author><name sortKey="Capri, Ettore" sort="Capri, Ettore" uniqKey="Capri E" first="Ettore" last="Capri">Ettore Capri</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247493" status="INCOMING"><orgName>OPERA Research Centre</orgName><desc><address><country key="IT"></country></address></desc><listRelation><relation active="#struct-309832" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-309832" type="direct"><org type="institution" xml:id="struct-309832" status="INCOMING"><orgName>Università Cattolica del Sacro Cuore</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Marchis, A" sort="Marchis, A" uniqKey="Marchis A" first="A." last="Marchis">A. Marchis</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-247493" status="INCOMING"><orgName>OPERA Research Centre</orgName><desc><address><country key="IT"></country></address></desc><listRelation><relation active="#struct-309832" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-309832" type="direct"><org type="institution" xml:id="struct-309832" status="INCOMING"><orgName>Università Cattolica del Sacro Cuore</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Italie</country></affiliation></author><author><name sortKey="Wilks, Martin" sort="Wilks, Martin" uniqKey="Wilks M" first="Martin" last="Wilks">Martin Wilks</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-64825" status="INCOMING"><orgName>University of Basel</orgName><desc><address><country key="CH"></country></address></desc></hal:affiliation><country>Suisse</country></affiliation></author></analytic><series><title level="j">Science of the Total Environment</title><idno type="ISSN">0048-9697</idno><imprint><date type="datePub">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="fr"><term>CHEMICAL EXPOSURE</term><term>ENVIRONMENTAL RISK ASSESSMENT</term><term>HAZARD ASSESSMENT</term><term>HUMAN RISK ASSESSMENT</term><term>INTEGRATION</term><term>SOCIO-ECONOMIC ANALYSIS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For more than a decade, the integration of human and environmental risk assessment (RA) has become an attractive vision. At the same time, existing European regulations of chemical substances such as REACH (EC Regulation No. 1907/2006), the Plant Protection Products Regulation (EC regulation 1107/2009) and Biocide Regulation (EC Regulation 528/2012) continue to ask for sector-specific RAs, each of which have their individual information requirements regarding exposure and hazard data, and also use different methodologies for the ultimate risk quantification. In response to this difference between the vision for integration and the current scientific and regulatory practice, the present paper outlines five medium-term opportunities for integrating human and environmental RA, followed by detailed discussions of the associated major components and their state of the art. Current hazard assessment approaches are analyzed in terms of data availability and quality, and covering non-test tools, the integrated testing strategy (ITS) approach, the adverse outcome pathway (AOP) concept, methods for assessing uncertainty, and the issue of explicitly treating mixture toxicity. With respect to exposure, opportunities for integrating exposure assessment are discussed, taking into account the uncertainty, standardization and validation of exposure modeling as well as the availability of exposure data. A further focus is on ways to complement RA by a socio-economic assessment (SEA) in order to better inform about risk management options. In this way, the present analysis, developed as part of the EU FP7 project HEROIC, may contribute to paving the way for integrating, where useful and possible, human and environmental RA in a manner suitable for its coupling with SEA.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li></country></list><tree><country name="France"><noRegion><name sortKey="Pery, Alexandre" sort="Pery, Alexandre" uniqKey="Pery A" first="Alexandre" last="Pery">Alexandre Pery</name></noRegion><name sortKey="Andres, Sandrine" sort="Andres, Sandrine" uniqKey="Andres S" first="Sandrine" last="Andres">Sandrine Andres</name><name sortKey="Brignon, Jean Marc" sort="Brignon, Jean Marc" uniqKey="Brignon J" first="Jean-Marc" last="Brignon">Jean-Marc Brignon</name><name sortKey="Ciffroy, Philippe" sort="Ciffroy, Philippe" uniqKey="Ciffroy P" first="Philippe" last="Ciffroy">Philippe Ciffroy</name><name sortKey="Mombelli, Enrico" sort="Mombelli, Enrico" uniqKey="Mombelli E" first="Enrico" last="Mombelli">Enrico Mombelli</name><name sortKey="Tebby, Cleo" sort="Tebby, Cleo" uniqKey="Tebby C" first="Cléo" last="Tebby">Cléo Tebby</name><name sortKey="Vergnaud, J C" sort="Vergnaud, J C" uniqKey="Vergnaud J" first="J. C." last="Vergnaud">J. C. Vergnaud</name></country><country name="Allemagne"><noRegion><name sortKey="Schuurmann, Gerrit" sort="Schuurmann, Gerrit" uniqKey="Schuurmann G" first="Gerrit" last="Schuurmann">Gerrit Schuurmann</name></noRegion><name sortKey="Backhaus, T" sort="Backhaus, T" uniqKey="Backhaus T" first="T." last="Backhaus">T. Backhaus</name><name sortKey="Faust, Michael" sort="Faust, Michael" uniqKey="Faust M" first="Michael" last="Faust">Michael Faust</name></country><country name="Suisse"><noRegion><name sortKey="Aicher, Lothar" sort="Aicher, Lothar" uniqKey="Aicher L" first="Lothar" last="Aicher">Lothar Aicher</name></noRegion><name sortKey="Tissot, Sylvie" sort="Tissot, Sylvie" uniqKey="Tissot S" first="Sylvie" last="Tissot">Sylvie Tissot</name><name sortKey="Wilks, Martin" sort="Wilks, Martin" uniqKey="Wilks M" first="Martin" last="Wilks">Martin Wilks</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Cronin, Mark" sort="Cronin, Mark" uniqKey="Cronin M" first="Mark" last="Cronin">Mark Cronin</name></noRegion><name sortKey="Frewer, L" sort="Frewer, L" uniqKey="Frewer L" first="L." last="Frewer">L. Frewer</name><name sortKey="Georgiou, S" sort="Georgiou, S" uniqKey="Georgiou S" first="S." last="Georgiou">S. Georgiou</name></country><country name="Grèce"><noRegion><name sortKey="Mattas, K" sort="Mattas, K" uniqKey="Mattas K" first="K." last="Mattas">K. Mattas</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Peijnenburg, W" sort="Peijnenburg, W" uniqKey="Peijnenburg W" first="W." last="Peijnenburg">W. Peijnenburg</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Capri, Ettore" sort="Capri, Ettore" uniqKey="Capri E" first="Ettore" last="Capri">Ettore Capri</name></noRegion><name sortKey="Marchis, A" sort="Marchis, A" uniqKey="Marchis A" first="A." last="Marchis">A. Marchis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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